Bioequivalence Evaluation of a Combine Formulation of Pioglitazone/ Metformin in Healthy Pakistani Volunteers

Numerous oral antidiabetic drugs with different mechanisms of action have been developed to lower glucose and delay the occurrence of serious complications in patients with type 2diabetes [1]. For glycemic control in diabetic patients, monotherapy with an oral antidiabetic agent is not adequate to achieve satisfactory blood glucose control [2]. Thus, combination regimens which include drugs with different and complementary mechanisms of action are recommended for achieving satisfactory blood glucose levels [3-7]. Hypoglycemic agents such as metformin, glipizide, glyburide, repaglinide, rosiglitazone, nateglinide, and pioglitazone are widely prescribed to control blood sugar levels. The majority of combination medicines available to date are based on metformin co-administration.